Activity Title

US: The ADVENT-HF Trial

Activity Title

The ADVENT-HF Trial

Statement of Need/Program Overview

This educational activity is designed to review, in detail, the results of the ADVENT-HF randomized clinical trial.  The effects of a particular type of adaptive servo-ventilation, triggered by changes in peak-flow (ASVPF), on obstructive and central sleep apnea (OSA and CSA, respectively) in patients with heart failure and reduced ejection fraction (HFrEF) will be presented.  The focus will be on the effects of ASVPF reduced on cardiovascular morbidity as well as on sleep structure and health-related quality of life.  The implications of these findings for clinical management of both OSA and CSA in patients with HFrEF will be reviewed.

Statement of Need/Program Overview

This educational activity is designed to review, in detail, the results of the ADVENT-HF randomized clinical trial.  The effects of a particular type of adaptive servo-ventilation, triggered by changes in peak-flow (ASVPF), on obstructive and central sleep apnea (OSA and CSA, respectively) in patients with heart failure and reduced ejection fraction (HFrEF) will be presented.  The focus will be on the effects of ASVPF reduced on cardiovascular morbidity as well as on sleep structure and health-related quality of life.  The implications of these findings for clinical management of both OSA and CSA in patients with HFrEF will be reviewed.

Target Audience

This activity is intended for medical professionals who have a clinical interest in the management of respiratory patients as seen by the following medical specialists: Pulmonologists, Pneumologists, Respirologists, Respiratory Physiotherapists, Respiratory Therapists (Hospital, Home), Thoracic Surgeons, Home Healthcare Providers, Critical Care Medicine Specialists, Internal Medicine Specialists, Primary Care Physicians (General and Family Practitioners), Advanced Practice Nurses, Nurse Practitioners, Physicians Assistants, Managed Care Medical Directors, and other Practitioners and Payers.

Target Audience

This activity is intended for medical professionals who have a clinical interest in the management of respiratory patients as seen by the following medical specialists: Pulmonologists, Pneumologists, Respirologists, Respiratory Physiotherapists, Respiratory Therapists (Hospital, Home), Thoracic Surgeons, Home Healthcare Providers, Critical Care Medicine Specialists, Internal Medicine Specialists, Primary Care Physicians (General and Family Practitioners), Advanced Practice Nurses, Nurse Practitioners, Physicians Assistants, Managed Care Medical Directors, and other Practitioners and Payers.

Educational Objectives

After completing the activity, the participant should be better able to:

• Examine the necessary elements in lab polysomnogram, and clinical assessment of patients with heart failure and sleep apnea.
• Describe the management of sleep apnea in heart failure according to phenotype of sleep apnea and heart failure.
• Describe how the results of the ADVENT-HF trial may change the management of heart failure patients with reduced ejection fraction and sleep apnea.
• Analyze the impact of the ADVENT-HF study findings on clinical practice by validating the inference that the high prevalence of obstructive sleep apnea (OSA) and central sleep apnea (CSA) in patients with heart failure with reduced ejection fraction (HFrEF) supports a lower threshold for performing diagnostic sleep studies.
• Identify which monitoring devices should be avoided as they do not reliably distinguish OSA from CSA.
• Explain the discrepancies between randomized trial results and epidemiological data regarding the treatment of OSA and CSA with Adaptive Servo-Ventilation with Positive Pressure Flow in patients with HFrEF.
• Identify best practices for treating patients with heart failure with HFrEF and coexisting OSA and CSA based on the ADVENT-HF study findings.

Educational Objectives

After completing the activity, the participant should be better able to:

• Examine the necessary elements in lab polysomnogram, and clinical assessment of patients with heart failure and sleep apnea.
• Describe the management of sleep apnea in heart failure according to phenotype of sleep apnea and heart failure.
• Describe how the results of the ADVENT-HF trial may change the management of heart failure patients with reduced ejection fraction and sleep apnea.
• Analyze the impact of the ADVENT-HF study findings on clinical practice by validating the inference that the high prevalence of obstructive sleep apnea (OSA) and central sleep apnea (CSA) in patients with heart failure with reduced ejection fraction (HFrEF) supports a lower threshold for performing diagnostic sleep studies.
• Identify which monitoring devices should be avoided as they do not reliably distinguish OSA from CSA.
• Explain the discrepancies between randomized trial results and epidemiological data regarding the treatment of OSA and CSA with Adaptive Servo-Ventilation with Positive Pressure Flow in patients with HFrEF.
• Identify best practices for treating patients with heart failure with HFrEF and coexisting OSA and CSA based on the ADVENT-HF study findings.

Faculty

Michael Arzt, MD
Professor of Internal Medicine, Sleep and Ventilation
Centre of Sleep Medicine
Department of Internal Medicine II
University Hospital Regensburg
Regensburg, Germany

T. Douglas Bradley, MD
Professor of Medicine
University Health Network Toronto General Hospital
Department of Medicine
Division of Respirology
Toronto, ON, Canada

Faculty

Michael Arzt, MD
Professor of Internal Medicine, Sleep and Ventilation
Centre of Sleep Medicine
Department of Internal Medicine II
University Hospital Regensburg
Regensburg, Germany

T. Douglas Bradley, MD
Professor of Medicine
University Health Network Toronto General Hospital
Department of Medicine
Division of Respirology
Toronto, ON, Canada

Program Agenda

Educational Presentation (2 hours 15 minutes)
Post Test and Evaluation (5 minutes)
Total Activity: (2 hours 20 minutes)

Program Agenda

Educational Presentation (2 hours 15 minutes)
Post Test and Evaluation (5 minutes)
Total Activity: (2 hours 20 minutes)

CME Provider Accreditation Statement

This activity is provided by Global Education Group (Global).

CME Provider Accreditation Statement

This activity is provided by Global Education Group.     

Physician Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Term Offering

This activity was released on November 15, 2025 and is valid for one year. Requests for credit must be made no later than November 15, 2026.

The above term offering is for the following accreditations: CME, AANP and ANCC

Physician Credit Designation

Global Education Group designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™.  Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Physician Accreditation Statement

Global Education Group is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. 

Nurse Practitioner Continuing Education

Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 2.25 contact hour(s) (which includes 0.0 hour(s) of pharmacology). 

Physician Credit Designation

Global Education Group designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 2.25 contact hour(s) (which includes 0.0 hour(s) of pharmacology). 

Physician Assistants

AAPA accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society. Physician assistants may receive a maximum of 2.25 hours of Category 1 credit for completing this program.

Nursing Accreditation Statement

Global Education Group is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

Nursing Continuing Education

Global Education Group is accredited as a provider of nursing continuing professional development by the American Nurses Credentialing Center's Commission on Accreditation.

This educational activity for 2.25 contact hours is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education

This educational activity for 2.25 contact hours including 0.0 pharmacotherapeutic contact hours is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

Term Offering - ACCME, AANP, ANCC

This activity was released on November 15, 2025 and is valid for one year. Requests for credit must be made no later than November 15, 2026.

Instructions to Receive Credit

In order to receive credit, participants must complete the course, score at least a 70% on the post test, complete the course evaluation form, and submit a credit application. Successful applicants will be able to download their certificate upon completion of these requirements. A copy of the certificate will also be sent to the email address provided in the credit application.

Review Date

The content for this activity was re-reviewed on 11/6/2025.

Global Contact Information

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com.

Global Contact Information

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com.

SUPPLEMENTAL ACCREDITATIONS

Credit Designation - AARC

This Non-traditional program has been approved for 2.25 contact hour Continuing Respiratory Care Education (CRCE) credit by the American Association for Respiratory Care; 9425 N. MacArthur Boulevard, Suite 100, Irving TX 75063

Credit Designation - AARC

This Non-traditional program has been approved for 2.25 contact hour Continuing Respiratory Care  Education (CRCE) credit by the American Association for Respiratory Care; 9425 N. MacArthur Boulevard, Suite 100, Irving TX 75063 Course #193482000

Term Offering - AARC / CRCE

This activity was released on February 2, 2025 and is valid for two years. Requests for credit must be made no later than February 2, 2027.

The above term offering is for the following accreditations: AARC

Term Offering

This activity was released on February 2, 2025 and is valid for two years. Requests for credit must be made no later than February 2, 2027.

The above term offering is for the following accreditations: AARC

Instructions to Receive Credit

In order to receive credit, participants must complete all of the course lessons. Participants must also score at least a 70% on the posttest. Upon completion of lessons and quizzes, you must also complete the evaluation form. Your certificate will be available to download upon completion of the evaluation.

How to Obtain AARC / CRCE Credit

Attendees are expected to review all academic materials before attempting to apply for credit. Successful completion of this activity will lead to the issuance of a certificate for 2.25 contact hour of CRCE approved continuing education.

To receive credit, please follow these steps:

• Complete the online registration (registration is free).
• Review all of the academic materials provided.
• Click on the CRCE link to apply for credit.
• Complete the online test and/or evaluation. Participants must receive a test score of at least 70% and answer all evaluation questions to receive a certificate.
• Qualified applicants will be provided with an online (printable) CRCE certificate based on their attendance and satisfactory completion of this academic activity.

System Requirements

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System Requirements

To view this educational activity, you will need a web browser with JavaScript and either Flash or HTML5 enabled. Nearly all modern web browsers will work.

Fee Information

There is no fee for this educational activity.

Fee Information

There is no fee for this educational activity.

Disclosure of Relevant Financial Relationships

Global adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global.  All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias. 

All relevant financial relationships have been mitigated.

Faculty Disclosures

The faculty have the following relevant financial relationships with ineligible companies:

The planners and managers at Global Education Group have no relevant financial relationships to disclose.

Disclosure of Relevant Financial Relationships

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global.  All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias. 

All relevant financial relationships have been mitigated.

Disclosure of Unlabeled Use:

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Faculty Disclosure

The faculty have the following relevant financial relationships with ineligible companies:

The planners and managers at Global Education Group have no relevant financial relationships to disclose.

Disclosure of Unlabeled Use:

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Commercial Support Statement

This activity is supported by an educational grant from Philips Respironics, Inc.

Policy on Privacy and Confidentiality

Global protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. Global and our joint sponsors will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

Global Education Group and Dane Garvin Ltd. maintain physical, electronic and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Policy on Privacy and Confidentiality

Global Education Group (Global) protects the privacy of personal and other information regarding participants, educational partners, and joint sponsors. Global and our joint sponsors will not release personally identifiable information to a third party without the individual's consent, except such information as is required for reporting purposes to the appropriate accrediting agency.

Global Education Group and Dane Garvin Ltd. maintain physical, electronic and procedural safeguards that comply with federal regulations to guard your nonpublic personal information.

Commercial Support Statement

This activity is supported by an educational grant from Philips Respironics, Inc.

Copyright

Copyright^© MEDtalks & Dane Garvin Ltd. All Rights Reserved. Permission for accreditation use granted to Global Education Group. 

Copyright

Copyright © MEDtalks & Dane Garvin Ltd. All Rights Reserved. Permission for accreditation use granted to Global Education Group (Global). 

Web interface provided by Dane Garvin Ltd.

Web interface provided by Dane Garvin Ltd.